RECEIVING A BLOOD TRANSFUSION:
WHAT EVERY PATIENT SHOULD KNOW
How many Americans need blood each year?
Nearly five million Americans receive blood transfusions each year. Blood is used to save the lives of patients who need surgery or
other medical treatment, for trauma victims of accidents and burns and for patients with cancer, hemophilia, and other serious
diseases.
Why would my doctor recommend that I receive blood?
You may need to receive blood in order to stabilize a medical condition or to save your life. The amount of blood that is given to
you is a decision your physician will make based on your particular needs. Details about why you may need blood will be best
explained by your doctor.
What steps are taken to make sure that the blood patients receive is safe?
There are many safeguards on our national blood supply to ensure safe blood for patients. First, blood is donated by volunteer
donors. Before giving blood, donors must answer questions about their health and risk factors for disease, and only a person with
a clean bill of health can give blood. Blood from each accepted donor goes through extensive testing. In addition to tests for blood
type, nine separate screening tests are run for evidence of infection with hepatitis, HIV, HTLV and syphilis. Finally, a carefully iden-
tified blood sample is tested against blood from the patient who will receive it, a process called crossmatch.
What are the risks of receiving blood?
If a blood transfusion is indicated during a surgical procedure or other medical treatment, the risks of NOT receiving blood far out-
weigh the risks of transfusion. Some patients may experience minor changes in the body's immune system after a transfusion,
causing mild symptoms, such as fever, chills or hives, which typically require little or no treatment. A small number of patients may
also react to donated blood by developing antibodies (immune reactions).
The transmission of disease and the destruction of red blood cells occur only very rarely, and seldom threaten life. The potential
risk of contracting AIDS from a blood transfusion has received a great deal of attention. But it is important to know that all donated
blood in the United States is tested for the AIDS virus, reducing the risk to a negligible level. When you consider the risks of trans-
fusion, it may be helpful to know that many common activities carry far greater risks — for example, smoking cigarettes, driving a
car or being pregnant.
What can I do to make sure that a safe supply of blood will be available should I, my friends, family or members of my
community need it?
It is very important that healthy Americans donate blood. This will guarantee that a safe and adequate blood supply is available for
patient care. Millions of lives are saved each year because of the availability of donated blood.
Do I have choices other than receiving blood from the community blood supply?
Yes, you may have other choices. Autologous blood transfusion refers to procedures in which you may serve as your own blood
donor. In preoperative autologous donation, your blood may be collected and stored before a scheduled surgery if blood use may
be required. In intraoperative and postoperative autologous transfusions, blood lost during surgery is saved and returned to the
patient. Directed donations can also be arranged in some cases from a person (usually a friend or relative) whom you select.
BLOOD TRANSFUSIONS
Why is blood transfused? Transfusions are given to replace blood lost during surgery, to replace blood lost because of acci-
dents, and to replace blood lost due to internal bleeding caused by a condition such as stomach ulcers. Transfusions are used in
the treatment of cancers such as leukemia and to treat different types of anemia such as sickle cell disease and thalassemia.
Is there a charge for receiving blood?
All blood centers and hospitals charge a processing fee to cover service costs such as donor recruitment; collecting, testing, pack-
aging, storing and distributing the blood; and administrative and staff costs. In the hospital, there are charges for matching and
administering a blood transfusion. Most health insurance policies cover these fees.
Are there any risks in receiving a transfusion?
As with any medical procedure, blood transfusions carry some risk. There is a remote chance of receiving blood of the wrong type.
In addition, several infectious diseases can be transmitted by blood transfusions. Among the viruses that may be transmitted by
blood are: human immunodeficiency virus (HIV), the virus that causes AIDS; human T-cell lymphotropic virus (HTLV-I); several
hepatitis viruses; cytomegalovirus (CMV), and West Nile virus (WNV). However, the very small risk of acquiring such a virus is
outweighed by the benefits of a blood transfusion that is needed.
What steps are taken to reduce the risks involved in receiving a transfusion?
Steps to ensure maximum transfusion safety involve both donor and recipient. Donors are screened very carefully using a detailed
questionnaire for health problems or circumstances that increase risk of transmitting infection. After blood has been drawn, it is
tested for numerous viruses and other potentially harmful disease agents, and positive or doubtful units are discarded. Donor
blood is tested for ABO, Rh and the presence of possibly dangerous blood group antibodies. After the recipient's blood has been
tested for ABO, Rh and the presence of blood group antibodies, donor units are selected that lack antigens that might react with
any antibodies present in the recipient. Additional checks are then performed to compare the specific donor unit selected with the
patient's blood.
What steps are taken to reduce the risk of acquiring hepatitis from transfusions?
First of all, donors are questioned extensively about possible exposure to hepatitis and behaviors that put them at increased risk
for hepatitis. Individuals who are found to have had an exposure or a risk factor are deferred from donation. In addition, several
tests are used to detect the presence of hepatitis B and C. Since the 1970s, all donor blood has been tested for direct evidence of
the hepatitis B virus. Since 1986, all donated blood has been screened for indirect evidence of hepatitis B, using a test for one of
the antibodies to hepatitis B (antibody to hepatitis B core antigen). A test for antibody to hepatitis C virus is also in place. Hepatitis
A is very rarely transmitted through blood transfusion.
What is cytomegalovirus (CMV)?
CMV is a common virus that causes a mild to unnoticeable infection in healthy people. About half of the adult population in the
United States has been infected with CMV. The virus can be transmitted by blood transfusion. Although it is not a problem for most
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